Rabbit Polyclonal Antibody to Gab2 (Phospho-Ser623)

包装: 1G|100G|500G|1KG|100KG

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别名:pp100; KIAA0571 ; GRB2-associated binder 2;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.Nishida K., Blood 93:1809-1816(1999)Nagase T., DNA Res. 5:31-39(1998)Taylor T.D., Nature 440:497-500(2006)

Description

This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.Nishida K., Blood 93:1809-1816(1999)Nagase T., DNA Res. 5:31-39(1998)Taylor T.D., Nature 440:497-500(2006)

Specification
Aliases	pp100; KIAA0571 ; GRB2-associated binder 2;
Entrez GeneID	9846;
Swissprot	Q9UQC2
WB Predicted band size	80kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of Serine 623(P-S-S(p)-P-S) derived from Human Gab2 .
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from 293 cells (Lane 2), HeLa cells (Lane 3) and HepG2 cells (Lane 4), using Gab2 (Phospho-Ser623) Antibody P40503. The lane on the left is treated with antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Gab2 (Phospho-Ser623) antibody P40503 (left)or the same antibody preincubated with blocking peptide (right).