Rabbit Polyclonal Antibody to GAD1/2

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别名:Glutamate decarboxylase 2; EC 4.1.1.15; Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.JB Travers, Chem Senses, Feb 2007; 32: 129 – 137.Rita Sulahian, Nucleic Acids Res., Mar 2006; 34: 1351 – 1357.Andrea Pillai, Development, Jan 2007; 134: 357 – 366.Dmytro P. Yevtushenko, J. Exp. Bot., Aug 2003; 54: 2001 – 2002.

Description

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.JB Travers, Chem Senses, Feb 2007; 32: 129 – 137.Rita Sulahian, Nucleic Acids Res., Mar 2006; 34: 1351 – 1357.Andrea Pillai, Development, Jan 2007; 134: 357 – 366.Dmytro P. Yevtushenko, J. Exp. Bot., Aug 2003; 54: 2001 – 2002.

Specification
Aliases	Glutamate decarboxylase 2; EC 4.1.1.15; Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase
Entrez GeneID	2571;2572;
Swissprot	Q4G154
WB Predicted band size	65kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from human GAD1/GAD2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from mouse brain cells, using GAD1/2 antibody P41802.
	Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using GAD1/2 antibody P41802.