Rabbit Polyclonal Antibody to GBE1

包装: 1G|100G|500G|1KG|100KG

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别名:4-alpha-glucan-branching enzyme, Brancher enzyme, Glycogen-branching enzyme, GBE1
应用:WB,ICC
反应种属:Human, Mouse
规格：50μl/100μl

Description
GBE1 is a glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain. Branching of the chains is essential to increase the solubility of the glycogen molecule and, consequently, in reducing the osmotic pressure within cells. Highest level of this enzyme are found in liver and muscle. Mutations in this gene are associated with glycogen storage disease IV (also known as Andersen’s disease).

Description

GBE1 is a glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain. Branching of the chains is essential to increase the solubility of the glycogen molecule and, consequently, in reducing the osmotic pressure within cells. Highest level of this enzyme are found in liver and muscle. Mutations in this gene are associated with glycogen storage disease IV (also known as Andersen’s disease).

Specification
Aliases	4-alpha-glucan-branching enzyme, Brancher enzyme, Glycogen-branching enzyme, GBE1
Entrez GeneID	2632
Swissprot	Q04446
WB Predicted band size	80.5kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This GBE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 amino acids from the Central region of human GBE1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
ICC	1/10-1/50

	Western blot analysis of GBE1 Antibody (Center) (Cat. #P30504) in HL-60 cell line lysates (35ug/lane). GBE1 (arrow) was detected using the purified Pab;
	Western blot analysis of GBE1 Antibody (Center) (Cat. #P30504) in mouse liver tissue lysates (35ug/lane).GBE1 (arrow) was detected using the purified Pab.
	Confocal immunofluorescent analysis of GBE1 Antibody (Center)(Cat#P30504) with HepG2 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).