中文 
别名:GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3应用:WB,IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
| Specification | |
|---|---|
| Aliases | GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3 |
| Entrez GeneID | 2645; |
| Swissprot | P35557 |
| WB Predicted band size | 52kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human glucokinase (hexokinase 4) |
| Formulation | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/2000 |
| IHC | 1/50-1/200 |
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Gel: 8%SDS-PAGE Lysate: 40ug HT-29 cell Primary antibody: 1/450 dilution Secondary antibody dilution: 1/8000 Exposure time: 40 seconds |
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Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using P42823 at dilution 1/40. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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