Rabbit Polyclonal Antibody to GR (Ab-211)

包装: 1G|100G|500G|1KG|100KG

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别名:GCR; GRL; GRL1; NR3C1; glucocorticoid receptor
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.Zhen Wang, Mol. Endocrinol., Mar 2007; 21: 625 – 634.Aaron L. Miller, Mol. Endocrinol., Jun 2005; 19: 1569 – 1583.Paul J. LeBlanc, J. Physiol., Jun 2004; 557: 559 – 570.Jos篓娄 Xavier-Neto, Hypertension, Jul 1999; 34: 31.

Description

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.Zhen Wang, Mol. Endocrinol., Mar 2007; 21: 625 – 634.Aaron L. Miller, Mol. Endocrinol., Jun 2005; 19: 1569 – 1583.Paul J. LeBlanc, J. Physiol., Jun 2004; 557: 559 – 570.Jos篓娄 Xavier-Neto, Hypertension, Jul 1999; 34: 31.

Specification
Aliases	GCR; GRL; GRL1; NR3C1; glucocorticoid receptor
Entrez GeneID	2908;
Swissprot	P04150
WB Predicted band size	95kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human GR around the phosphorylation site of serine 211 (N-E-S-P-W).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/500

	Western blot analysis of extracts from HeLa cells treated with PMA (125ng/ml, 30min), using GR (Ab-211) antibody P41636.
	Western blot analysis of extracts from K562 cells (Lane 2), using GR (Ab-211) antiobdy P41636. The lane on the left is treated with synthesized peptide.
	Immunofluorescence analysis of A549 cells, using GR (Ab-211) antibody P41636.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GR (Ab-211) antibody P41636.