Rabbit Polyclonal Antibody to GR (Ab-226)

包装: 1G|100G|500G|1KG|100KG

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别名:GCR; GRL; GRL1; NR3C1; glucocorticoid receptor
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.Kyung Jin Kwak, J. Exp. Bot., Nov 2005; 56: 3007 – 3016. Maite de Llanos, Hum. Reprod., Jan 2005; 20: 216 – 220. M. Lynch, Mol. Hum. Reprod., Jul 2005; 11: 507 – 512. Valeriya P. Makarenkova, J. Immunol., Feb 2006; 176: 2085 – 2094.

Description

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.Kyung Jin Kwak, J. Exp. Bot., Nov 2005; 56: 3007 – 3016. Maite de Llanos, Hum. Reprod., Jan 2005; 20: 216 – 220. M. Lynch, Mol. Hum. Reprod., Jul 2005; 11: 507 – 512. Valeriya P. Makarenkova, J. Immunol., Feb 2006; 176: 2085 – 2094.

Specification
Aliases	GCR; GRL; GRL1; NR3C1; glucocorticoid receptor
Entrez GeneID	2908;
Swissprot	P04150
WB Predicted band size	90kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human GR around the phosphorylation site of serine 226/234/246 (L-L-S-P-L).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from Jurkat cells, treated with EGF (200ng/ml, 15mins), using GR (Ab-226) antibody P41643.
	Western blot analysis of extracts from JK cells (Lane 2) and K562 cells (Lane 3), using GR(Ab-226) antiobdy P41643. The lane on the left is treated with synthesized peptide.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using GR (Ab-226) antibody P41643.