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别名:GCCR; GCR; GRL; NR3C1;应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.Wehmeyer L, Du Toit A, Lang DM, Hapgood JP (2014) J Biol Chem 289, 10235-51 Bouazza B, et al. (2014) Am J Respir Cell Mol Biol 50, 301-15 Lee MS, et al. (2013) Behav Brain Res 236, 56-61 |
| Specification | |
|---|---|
| Aliases | GCCR; GCR; GRL; NR3C1; |
| Entrez GeneID | 2908; |
| Swissprot | P04150 |
| WB Predicted band size | 86kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of serine 226 (L-L-S(p)-P-L) derived from Human GR. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from Jurkat cells treated with EGF using Phospho-GR (Ser226) antibody P40575.The lane on the right is treated with the antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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