中文 
别名:GLUR8; mGlu8; GPRC1H; MGLUR8应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl
| Description |
|---|
| L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Specification | |
|---|---|
| Aliases | GLUR8; mGlu8; GPRC1H; MGLUR8 |
| Entrez GeneID | 2918; |
| Swissprot | O00222 |
| WB Predicted band size | 56kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human glutamate receptor, metabotropic 8 |
| Formulation | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/2000 |
| IHC | 1/50-1/200 |
 |
Gel: 8%SDS-PAGE Lysates (from left to right): Mouse brain tissue Amount of lysate: 40ug per lane Primary antibody: 1/1200 dilution Secondary antibody dilution: 1/8000 Exposure time: 5 minutes |
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Immunohistochemical analysis of paraffin-embedded Human ovarain cancer tissue using P42858 at dilution 1/120. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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