Rabbit Polyclonal Antibody to GRN

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别名:GEP; GP88; PEPI; PGRN; CLN11; PCDGF
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Description

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Specification
Aliases	GEP; GP88; PEPI; PGRN; CLN11; PCDGF
Swissprot	P28799
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein of human GRN
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/50-1/200
ELISA	1/5000-1/10000

	The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07539(GRN Antibody) at dilution 1/90. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07539(GRN Antibody) at dilution 1/90. (Original magnification: ×200)