Rabbit Polyclonal Antibody to HBG1

包装: 1G|100G|500G|1KG|100KG

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别名:Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1
应用:WB
反应种属:Human
规格：50μl/100μl

Description
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5′-epsilon — gamma-G — gamma-A — delta — beta–3′.

Description

The gamma globin genes (HBG1 and HBG2) are normally
expressed in the fetal liver, spleen and bone marrow. Two gamma
chains together with two alpha chains constitute fetal hemoglobin
(HbF) which is normally replaced by adult hemoglobin (HbA) at
birth. In some beta-thalassemias and related conditions, gamma
chain production continues into adulthood. The two types of gamma
chains differ at residue 136 where glycine is found in the G-gamma
product (HBG2) and alanine is found in the A-gamma product (HBG1).
The former is predominant at birth. The order of the genes in the
beta-globin cluster is: 5′-epsilon — gamma-G — gamma-A — delta
— beta–3′.

Specification
Aliases	Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1
Entrez GeneID	3047
Swissprot	P69891
WB Predicted band size	16.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This HBG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the Central region of human HBG1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000

	Western blot analysis of HBG1 (arrow) using rabbit polyclonal HBG1 Antibody (Center) (Cat. #P31324). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HBG1 gene.
	HBG1 Antibody (Center) (Cat. #P31324) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HBG1 antibody detected the HBG1 protein (arrow).