Rabbit Polyclonal Antibody to HDAC1

包装: 1G|100G|500G|1KG|100KG

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别名:Histone deacetylase 10; HD10;
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Jenny J. Tong, Nucleic Acids Res., Mar 2002; 30: 1114 – 1123.Hung-Ying Kao, J. Biol. Chem., Jan 2002; 277: 187 – 193.Denise D. Fischer, J. Biol. Chem., Feb 2002; 277: 6656 – 6666.Matthew H. Brush, J. Biol. Chem., Feb 2004; 279: 7685 – 7691.

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Jenny J. Tong, Nucleic Acids Res., Mar 2002; 30: 1114 – 1123.Hung-Ying Kao, J. Biol. Chem., Jan 2002; 277: 187 – 193.Denise D. Fischer, J. Biol. Chem., Feb 2002; 277: 6656 – 6666.Matthew H. Brush, J. Biol. Chem., Feb 2004; 279: 7685 – 7691.

Specification
Aliases	Histone deacetylase 10; HD10;
Entrez GeneID	83933;
Swissprot	Q969S8
WB Predicted band size	75kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human HDAC10.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from COS7 cells, using HDAC10 antibody P41813.
	Western blot analysis of extracts from JK cells (Lane 2) and cos-7 cells (Lane 3), using HDAC10 antiobdy P41813. The lane on the left is treated with synthesized peptide.
	Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using HDAC10 antibody P41813.