Rabbit Polyclonal Antibody to HDAC4 (Ab-632)

包装: 1G|100G|500G|1KG|100KG

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别名:HD4; Histone deacetylase 4; KIAA0288;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.Wang AH, et al. (2000) Mol Cell Biol. 20(18): 6904-6912.Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97(14): 7835-7840.

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.Wang AH, et al. (2000) Mol Cell Biol. 20(18): 6904-6912.Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97(14): 7835-7840.

Specification
Aliases	HD4; Histone deacetylase 4; KIAA0288;
Entrez GeneID	9759;
Swissprot	P56524
WB Predicted band size	119kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human HDAC4 around the phosphorylation site of serine 632.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000

	Western blot analysis of extracts from HeLa/Jurkat cells, using HDAC4 (Ab-632) antibody P41691.
	Western blot analysis of extracts from Hela cells (Lane 2), using HDAC4 (Ab-632) antiobdy P41691. The lane on the left is treated with synthesized peptide.