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别名:HD7a; HDA7; HDAC7A; Histone;应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors By similarity. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.Walsh M.J., Submitted (FEB-2000).Zelent A., Submitted (MAY-2003).Sugano S., Nat. Genet. 36:40-45(2004). |
| Specification | |
|---|---|
| Aliases | HD7a; HDA7; HDAC7A; Histone; |
| Entrez GeneID | 51564; |
| Swissprot | Q8WUI4 |
| WB Predicted band size | 103kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human HDAC7A around the phosphorylation site of serine 155 (T-V-S(p)-E-P). |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
 |
Western blot analysis of extracts from JK cells (Lane 2), using HDAC7A (Ab-155) antiobdy P41772. The lane on the left is treated with synthesized peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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