Rabbit Polyclonal Antibody to Heparin Cofactor II

包装: 1G|100G|500G|1KG|100KG

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别名:Heparin cofactor 2 [Precursor]; Heparin cofactor II; HC-II; Protease inhibitor leuserpin 2; HLS2
应用:WB,IHC,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.Blinder M.A., Biochemistry 27:752-759(1988).Herzog R., Biochemistry 30:1350-1357(1991).Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).

Description

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.Blinder M.A., Biochemistry 27:752-759(1988).Herzog R., Biochemistry 30:1350-1357(1991).Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).

Specification
Aliases	Heparin cofactor 2 [Precursor]; Heparin cofactor II; HC-II; Protease inhibitor leuserpin 2; HLS2
Entrez GeneID	3053;
Swissprot	P05546
WB Predicted band size	57kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human Heparin Cofactor II.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/200

	Immunofluorescence analysis of HepG2 cells, using Heparin Cofactor II antibody P41900.
	Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Heparin Cofactor II antibody P41900.