Rabbit Polyclonal Antibody to HES6

包装: 1G|100G|500G|1KG|100KG

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别名:Transcription cofactor HES-6; Hairy and enhancer of split 6; C-HAIRY1; HES6;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation By similarity. UniProtKB Q9JHE6Bae S.-K., Development 127:2933-2943(2000).Vasiliauskas D., Mech. Dev. 98:133-137(2000).Ota T., Nat. Genet. 36:40-45(2004).

Description

Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation By similarity. UniProtKB Q9JHE6Bae S.-K., Development 127:2933-2943(2000).Vasiliauskas D., Mech. Dev. 98:133-137(2000).Ota T., Nat. Genet. 36:40-45(2004).

Specification
Aliases	Transcription cofactor HES-6; Hairy and enhancer of split 6; C-HAIRY1; HES6;
Entrez GeneID	55502;
Swissprot	Q96HZ4
WB Predicted band size	30kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from N-terminal of human HES6.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.