Rabbit Polyclonal Antibody to Hexokinase-3

包装: 1G|100G|500G|1KG|100KG

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别名:Hexokinase-3; EC 2.7.1.1; Hexokinase type III; HK III; HK3
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Hexokinase catalyzes the conversion of glucose to glucose-6-phosphate, the first step in glycolysis. Four distinct mammalian hexokinase isoforms, designated as hexokinase I, II, III, and IV (glucokinase), have been identified. Hexokinases I, II, and III are associated with the outer mitochondrial membrane and are critical for maintaining an elevated rate of aerobic glycolysis in cancer cells (Warburg Effect) (1) in order to compensate for the increased energy demands associated with rapid cell growth and proliferation (2,3).Furuta H., Genomics 36:206-209(1996).Palma F., Mol. Cell. Biochem. 155:23-29(1996).Sjoeblom T., Science 314:268-274(2006).

Description

Hexokinase catalyzes the conversion of glucose to glucose-6-phosphate, the first step in glycolysis. Four distinct mammalian hexokinase isoforms, designated as hexokinase I, II, III, and IV (glucokinase), have been identified. Hexokinases I, II, and III are associated with the outer mitochondrial membrane and are critical for maintaining an elevated rate of aerobic glycolysis in cancer cells (Warburg Effect) (1) in order to compensate for the increased energy demands associated with rapid cell growth and proliferation (2,3).Furuta H., Genomics 36:206-209(1996).Palma F., Mol. Cell. Biochem. 155:23-29(1996).Sjoeblom T., Science 314:268-274(2006).

Specification
Aliases	Hexokinase-3; EC 2.7.1.1; Hexokinase type III; HK III; HK3
Entrez GeneID	3101;
Swissprot	P52790
WB Predicted band size	99kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human Hexokinase-3.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.