Rabbit Polyclonal Antibody to HGS

包装: 1G|100G|500G|1KG|100KG

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别名:HGS; Hepatocyte growth factor-regulated tyrosine kinase substrate; IMOS-1;
应用:WB,IHC,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.Asao H., J. Biol. Chem. 272:32785-32791(1997).Lu L., Gene 213:125-132(1998).Scoles D.R., Hum. Mol. Genet. 9:1567-1574(2000).

Description

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.Asao H., J. Biol. Chem. 272:32785-32791(1997).Lu L., Gene 213:125-132(1998).Scoles D.R., Hum. Mol. Genet. 9:1567-1574(2000).

Specification
Aliases	HGS; Hepatocyte growth factor-regulated tyrosine kinase substrate; IMOS-1;
Entrez GeneID	9146;
Swissprot	O14964
WB Predicted band size	86kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human HGS.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/500

	Western blot analysis of extracts from 293 cells and JK cells, using HGS antibody P41860.
	Immunofluorescence analysis of HUVEC cells, using HGS antibody P41860.
	Immunohistochemistry analysis of paraffin-embedded human testis tissue using HGS antibody P41860.