Rabbit Polyclonal Antibody to HIST1H2BL (N-term)

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别名:Histone H2B type 1-L, Histone H2Bc, H2B/c, HIST1H2BL, H2BFC
应用:WB,FCM
反应种属:Human
规格：50μl/100μl

Description
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

Description

Histones are basic nuclear proteins that are responsible
for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A,
H2B, H3, and H4) form an octamer, around which approximately 146 bp
of DNA is wrapped in repeating units, called nucleosomes. The
linker histone, H1, interacts with linker DNA between nucleosomes
and functions in the compaction of chromatin into higher order
structures. This gene is intronless and encodes a member of the
histone H2B family. Transcripts from this gene lack polyA tails but
instead contain a palindromic termination element. This gene is
found in the small histone gene cluster on chromosome 6p22-p21.3.

Specification
Aliases	Histone H2B type 1-L, Histone H2Bc, H2B/c, HIST1H2BL, H2BFC
Entrez GeneID	8340
Swissprot	Q99880
WB Predicted band size	14.0kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This HIST1H2BL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2BL.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
FCM	1/10-1/50

	HIST1H2BL Antibody (N-term) (Cat. #P31136) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HIST1H2BL antibody detected the HIST1H2BL protein (arrow).
	HIST1H2BL Antibody (N-term) (Cat. #P31136) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.