Rabbit Polyclonal Antibody to Histone H2B

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别名:Histone H2B type 1-H; H2B.j; H2B/j; HIST1H2BH; H2BFJ
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Albig W., Genomics 40:314-322(1997).Marzluff W.F., Genomics 80:487-498(2002).Mungall A.J., Nature 425:805-811(2003).

Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Albig W., Genomics 40:314-322(1997).Marzluff W.F., Genomics 80:487-498(2002).Mungall A.J., Nature 425:805-811(2003).

Specification
Aliases	Histone H2B type 1-H; H2B.j; H2B/j; HIST1H2BH; H2BFJ
Entrez GeneID	8345;
Swissprot	Q93079
WB Predicted band size	18kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human Histone H2B.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/500

	Western blot analysis of extracts from A549 cells, using Histone H2B antibody P42075.
	Immunofluorescence analysis of HeLa cells, using Histone H2B antibody P42075.
	Immunohistochemistry analysis of paraffin-embedded human brain tissue using Histone H2B antibody P42075.