Rabbit Polyclonal Antibody to HMGA2

包装: 1G|100G|500G|1KG|100KG

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别名:High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC
应用:WB,FCM
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Description

This gene encodes a protein that belongs to the
non-histone chromosomal high mobility group (HMG) protein family.
HMG proteins function as architectural factors and are essential
components of the enhancesome. This protein contains structural
DNA-binding domains and may act as a transcriptional regulating
factor. Identification of the deletion, amplification, and
rearrangement of this gene that are associated with myxoid
liposarcoma suggests a role in adipogenesis and mesenchymal
differentiation. A gene knock out study of the mouse counterpart
demonstrated that this gene is involved in diet-induced obesity.
Alternate transcriptional splice variants, encoding different
isoforms, have been characterized.

Specification
Aliases	High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC
Entrez GeneID	8091
Swissprot	P52926
WB Predicted band size	11.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This HMGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human HMGA2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
FCM	1/10-1/50

	HMGA2 Antibody (C-term) (Cat. #P30672) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HMGA2 antibody detected the HMGA2 protein (arrow).
	HMGA2 Antibody (C-term) (Cat. #P30672) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.