Rabbit Polyclonal Antibody to HMGN1 (N-term)

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别名:Non-histone chromosomal protein HMG-14, High mobility group nucleosome-binding domain-containing protein 1, HMGN1, HMG14
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.

Description

Chromosomal protein HMG14 and its close analog HMG17 (MIM
163910) bind to the inner side of the nucleosomal DNA, potentially
altering the interaction between the DNA and the histone octamer.
The 2 proteins may be involved in the process that maintains
transcribable genes in a unique chromatin conformation. Their
ubiquitous distribution and relative abundance, as well as the high
evolutionary conservation of the DNA-binding domain of the HMG14
family of proteins, suggest that they may be involved in an
important cellular function.

Specification
Aliases	Non-histone chromosomal protein HMG-14, High mobility group nucleosome-binding domain-containing protein 1, HMGN1, HMG14
Entrez GeneID	3150
Swissprot	P05114
WB Predicted band size	10.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This HMGN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HMGN1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	HMGN1 Antibody (N-term) (Cat. #P31416) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HMGN1 antibody detected the HMGN1 protein (arrow).
	Western blot analysis of HMGN1 (arrow) using rabbit polyclonal HMGN1 Antibody (N-term) (Cat. #P31416). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HMGN1 gene.
	HMGN1 Antibody (N-term) (P31416)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HMGN1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.