Rabbit Polyclonal Antibody to HP1 alpha (Ab-92)

包装: 1G|100G|500G|1KG|100KG

现货支持定制

QQ咨询
| 微信咨询

满200元免运费
正品保障提供发票
现货闪电当时发货

别名:antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Component of heterochromatin that recognizes and binds histone H3 tails methylated at ‘Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ‘Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.Saunders W.S., J. Cell Sci. 104:573-582(1993).The MGC Project Team; Genome Res. 14:2121-2127(2004).Ye Q., J. Biol. Chem. 271:14653-14656(1996).

Description

Component of heterochromatin that recognizes and binds histone H3 tails methylated at ‘Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ‘Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.Saunders W.S., J. Cell Sci. 104:573-582(1993).The MGC Project Team; Genome Res. 14:2121-2127(2004).Ye Q., J. Biol. Chem. 271:14653-14656(1996).

Specification
Aliases	antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A
Entrez GeneID	23468;
Swissprot	P45973
WB Predicted band size	24kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human HP1 alpha around the phosphorylation site of serine 92 (R-K-S(p)-N-F).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from Jurkat cells, treated with insulin (0.01U/ml, 15mins), using HP1 alpha (Ab-92) antibody P41740.
	Immunohistochemistry analysis of paraffin-embedded human braina tissue using HP1 alpha (Ab-92) antibody P41740.