Rabbit Polyclonal Antibody to HS2ST1

包装: 1G|100G|500G|1KG|100KG

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别名:Heparan sulfate 2-O-sulfotransferase 1, 2-O-sulfotransferase, 2OST, 282-, HS2ST1, HS2ST, KIAA0448
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.

Description

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.

Specification
Aliases	Heparan sulfate 2-O-sulfotransferase 1, 2-O-sulfotransferase, 2OST, 282-, HS2ST1, HS2ST, KIAA0448
Entrez GeneID	9653
Swissprot	Q7LGA3
WB Predicted band size	41.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This HS2ST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-200 amino acids from the Central region of human HS2ST1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Application
WB	1/1000
IHC	1/100-1/500

	Western blot analysis of anti-HS2ST1 Antibody (Center) Pab (Cat.#P30180) in Ramos and CEM cell line lysates. HS2ST1(arrow) was detected using the purified Pab.
	Western blot analysis of anti-HS2ST1 Antibody (Center) Pab (Cat.#P30180) in 293 cell line lysates transiently transfected with the HS2ST1 gene (2ug/lane). HS2ST1(arrow) was detected using the purified Pab.
	Western blot analysis of anti-HS2ST1 Antibody (Center) Pab (Cat.#P30180) in 293 cell line lysates transiently transfected with the HS2ST1 gene (2ug/lane). HS2ST1 Antibody (Center)(arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human brain tissue reacted with HS2ST1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.