Rabbit Polyclonal Antibody to HSD11B1

包装: 1G|100G|500G|1KG|100KG

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别名:Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-DH; 11-beta-hydroxysteroid;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol By similarity.Tannin G.M., J. Biol. Chem. 266:16653-16658(1991).Draper N., J. Clin. Endocrinol. Metab. 87:4984-4990(2002).Ota T., Nat. Genet. 36:40-45(2004) .

Description

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol By similarity.Tannin G.M., J. Biol. Chem. 266:16653-16658(1991).Draper N., J. Clin. Endocrinol. Metab. 87:4984-4990(2002).Ota T., Nat. Genet. 36:40-45(2004) .

Specification
Aliases	Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-DH; 11-beta-hydroxysteroid;
Entrez GeneID	3290;
Swissprot	P28845
WB Predicted band size	32kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from N-terminal of human HSD11B1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HuvEc cells, using HSD11B1 antibody P42374.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using HSD11B1 antibody P42374.