Rabbit Polyclonal Antibody to HYAL1

包装: 1G|100G|500G|1KG|100KG

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别名:Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.

Description

This gene encodes a lysosomal hyaluronidase.
Hyaluronidases intracellularly degrade hyaluronan, one of the major
glycosaminoglycans of the extracellular matrix. Hyaluronan is
thought to be involved in cell proliferation, migration and
differentiation. This enzyme is active at an acidic pH and is the
major hyaluronidase in plasma. Mutations in this gene are
associated with mucopolysaccharidosis type IX, or hyaluronidase
deficiency. The gene is one of several related genes in a region of
chromosome 3p21.3 associated with tumor suppression. Multiple
transcript variants encoding different isoforms have been found for
this gene.

Specification
Aliases	Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1
Entrez GeneID	3373
Swissprot	Q12794
WB Predicted band size	48.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This HYAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human HYAL1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	HYAL1 Antibody (C-term) (Cat. #P31549) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HYAL1 antibody detected the HYAL1 protein (arrow).
	HYAL1 Antibody (C-term) (P31549)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HYAL1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.