Rabbit Polyclonal Antibody to HYAL2

包装: 1G|100G|500G|1KG|100KG

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别名:Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5′ UTR.

Description

This gene encodes a weak acid-active hyaluronidase. The
encoded protein is similar in structure to other more active
hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major
glycosaminoglycans of the extracellular matrix. Hyaluronan and
fragments of hyaluronan are thought to be involved in cell
proliferation, migration and differentiation. Although it was
previously thought to be a lysosomal hyaluronidase that is active
at a pH below 4, the encoded protein is likely a GPI-anchored cell
surface protein. This hyaluronidase serves as a receptor for the
oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of
several related genes in a region of chromosome 3p21.3 associated
with tumor suppression. This gene encodes two alternatively spliced
transcript variants which differ only in the 5′ UTR.

Specification
Aliases	Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2
Entrez GeneID	8692
Swissprot	Q12891
WB Predicted band size	53.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human HYAL2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	Western blot analysis of HYAL2 Antibody (Center) Pab (Cat. #P31096) pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate. HYAL2 Antibody (Center) (arrow) was detected using the purified Pab.
	HYAL2 Antibody (Center) (Cat. #P31096)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HYAL2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.