Rabbit Polyclonal Antibody to IκB-α (Ab-32/36)

包装: 1G|100G|500G|1KG|100KG

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别名:I-kappa-B-alpha; IkappaBalpha; IKBA; MAD3; Major histocompatibility complex enhancer-binding protein MAD3
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.Mattioli I, et al. (2004)J Immunol; 172(10): 6336-44.Courtois G, et al. (2003)J Clin Invest; 112(7): 1108-15.Nair A, et al. (2003) Oncogene; 22(1): 50-8.Fan C, et al. (2002)J Cell Sci; 115(Pt 24): 4843-53.Schubert SY, et al. (2002)FASEB J; 16(14): 193

Description

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.Mattioli I, et al. (2004)J Immunol; 172(10): 6336-44.Courtois G, et al. (2003)J Clin Invest; 112(7): 1108-15.Nair A, et al. (2003) Oncogene; 22(1): 50-8.Fan C, et al. (2002)J Cell Sci; 115(Pt 24): 4843-53.Schubert SY, et al. (2002)FASEB J; 16(14): 193

Specification
Aliases	I-kappa-B-alpha; IkappaBalpha; IKBA; MAD3; Major histocompatibility complex enhancer-binding protein MAD3
Entrez GeneID	4792;
Swissprot	P25963
WB Predicted band size	39kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human IκB-α around the phosphorylation site of Serine 32/36.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from MCF7 cells, treated with TNF-α, using IkappaB-alpha (Ab-32/36) antibody P41693.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IkappaB-alpha (Ab-32/36) antibody P41693.