Rabbit Polyclonal Antibody to IFIT5

包装: 1G|100G|500G|1KG|100KG

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别名:IFIT-5; interferon-induced protein with tetratricopeptide repeats 5; retinoic acid- and interferon-inducible 58 kDa protein; RI58;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5′-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2′-O-methylation of the 5′ cap and bear a 5′-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.Rogers J., Nature 429:375-381(2004).Venter J.C., Submitted (SEP-2005).Bennett K.L., Submitted (OCT-2008).

Description

Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5′-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2′-O-methylation of the 5′ cap and bear a 5′-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.Rogers J., Nature 429:375-381(2004).Venter J.C., Submitted (SEP-2005).Bennett K.L., Submitted (OCT-2008).

Specification
Aliases	IFIT-5; interferon-induced protein with tetratricopeptide repeats 5; retinoic acid- and interferon-inducible 58 kDa protein; RI58;
Entrez GeneID	24138;
Swissprot	Q13325
WB Predicted band size	50kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human IFIT5.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.