中文 
别名:CD221; kinase IGF1R; IGF1R;应用:IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.Ullrich A., EMBO J. 5:2503-2512(1986)Abbot A.M., J. Biol. Chem. 267:10759-10763(1992)The MGC Project Team;Genome Res. 14:2121-2127(2004) |
| Specification | |
|---|---|
| Aliases | CD221; kinase IGF1R; IGF1R; |
| Entrez GeneID | 3480; |
| Swissprot | P08069 |
| WB Predicted band size | 154kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 1346(Q-P-Y(p)-A-H) derived from Human IGF1R . |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| IHC | 1/50-1/100 |
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Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF1R (Phospho-Tyr1346) antibody P40421 (left)or the same antibody preincubated with blocking peptide (right). |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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