Rabbit Polyclonal Antibody to IGF2R (Phospho-Ser2409)

包装: 1G|100G|500G|1KG|100KG

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别名:CI-MPR; CI-MPR; MPR300; MPRI;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.Morgan D.O., Nature 329:301-307(1987)Oshima A., J. Biol. Chem. 263:2553-2562(1988)Killian J.K., Mamm. Genome 10:74-77(1999)

Description

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.Morgan D.O., Nature 329:301-307(1987)Oshima A., J. Biol. Chem. 263:2553-2562(1988)Killian J.K., Mamm. Genome 10:74-77(1999)

Specification
Aliases	CI-MPR; CI-MPR; MPR300; MPRI;
Entrez GeneID	3482;
Swissprot	P11717
WB Predicted band size	300kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of Serine 2409(Q-D-S(p)-E-D) derived from Human IGF2R.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from COS-7 cells treated with UV using IGF2R (Phospho-Ser2409) Antibody P40416.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using IGF2R (Phospho-Ser2409) antibody P40416 (left)or the same antibody preincubated with blocking peptide (right).