Rabbit Polyclonal Antibody to IKK- beta (Phospho-Tyr188)

包装: 1G|100G|500G|1KG|100KG

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别名:I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK2; IkBKB
应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.Darwech I, Otero JE, Alhawagri MA, Abu-Amer Y (2010)J Biol Chem 285, 25522-30 Huang WC, Chen JJ, Inoue H, Chen CC (2003) J Immunol 170, 4767-75 Huang WC, Chen JJ, Chen CC (2003)J Biol Chem 278, 9944-52

Description

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.Darwech I, Otero JE, Alhawagri MA, Abu-Amer Y (2010)J Biol Chem 285, 25522-30 Huang WC, Chen JJ, Inoue H, Chen CC (2003) J Immunol 170, 4767-75 Huang WC, Chen JJ, Chen CC (2003)J Biol Chem 278, 9944-52

Specification
Aliases	I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK2; IkBKB
Entrez GeneID	3551;
Swissprot	O14920
WB Predicted band size	87kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 188 (L-Q-Y(p)-L-A) derived from Human IKK- beta.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000

Western blot analysis of extracts from COS7 tissue using IKK- beta (Phospho-Tyr188) antibody P40568.The lane on the right is treated with the antigen-specific peptide.

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

Rabbit Polyclonal Antibody to IKK- beta (Phospho-Tyr188)

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