Rabbit Polyclonal Antibody to IL13

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别名:Interleukin-13, IL-13, IL13, NC30
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq].

Description

This gene encodes an immunoregulatory cytokine produced
primarily by activated Th2 cells. This cytokine is involved in
several stages of B-cell maturation and differentiation. It
up-regulates CD23 and MHC class II expression, and promotes IgE
isotype switching of B cells. This cytokine down-regulates
macrophage activity, thereby inhibits the production of
pro-inflammatory cytokines and chemokines. This cytokine is found
to be critical to the pathogenesis of allergen-induced asthma but
operates through mechanisms independent of IgE and eosinophils.
This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on
chromosome 5q, with this gene particularly close to IL4. [provided
by RefSeq].

Specification
Aliases	Interleukin-13, IL-13, IL13, NC30
Entrez GeneID	3596
Swissprot	P35225
WB Predicted band size	15.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This IL13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from the C-terminal region of human IL13.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
ICC	1/10-1/50

	IL13 Antibody (C-term) (Cat. #P31332) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IL13 antibody detected the IL13 protein (arrow).
	Confocal immunofluorescent analysis of IL13 Antibody (C-term) (Cat#AP7989b) with P31332 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
	IL13 Antibody (C-term) (P31332)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IL13 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.