Rabbit Polyclonal Antibody to IMPDH1

包装: 1G|100G|500G|1KG|100KG

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别名:Inosine-5′-monophosphate dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 1 {ECO:0000255|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-I, IMPDH1 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD1
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5′-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.

Description

The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5′-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.

Specification
Aliases	Inosine-5′-monophosphate dehydrogenase 1 {ECO:0000255\|HAMAP-Rule:MF_03156}, IMP dehydrogenase 1 {ECO:0000255\|HAMAP-Rule:MF_03156}, IMPD 1 {ECO:0000255\|HAMAP-Rule:MF_03156}, IMPDH 1 {ECO:0000255\|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255\|HAMAP-Rule:MF_03156}, IMPDH-I, IMPDH1 {ECO:0000255\|HAMAP-Rule:MF_03156}, IMPD1
Entrez GeneID	3614
Swissprot	P20839
WB Predicted band size	55.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This IMPDH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-514 amino acids from the C-terminal region of human IMPDH1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
ICC	1/10-1/50

	IMPDH1 Antibody (C-term) (Cat. #P31308) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the IMPDH1 antibody detected the IMPDH1 protein (arrow).
	Confocal immunofluorescent analysis of IMPDH1 Antibody (C-term) (Cat#P31308) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
	IMPDH1 Antibody (C-term) (P31308)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IMPDH1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.