Rabbit Polyclonal Antibody to IRS-1 (Ab-312)

包装: 1G|100G|500G|1KG|100KG

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别名:Insulin receptor substrate-1; IRS-1; IRS1;
应用:WB,IHC,ICC
反应种属:Human,Mouse
规格：50μl/100μl

Description
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit By similarity.Araki E., Diabetes 42:1041-1054(1993).Nishiyama M., Biochem. Biophys. Res. Commun. 183:280-285(1992).The MGC Project Team; Genome Res. 14:2121-2127(2004)

Description

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit By similarity.Araki E., Diabetes 42:1041-1054(1993).Nishiyama M., Biochem. Biophys. Res. Commun. 183:280-285(1992).The MGC Project Team; Genome Res. 14:2121-2127(2004)

Specification
Aliases	Insulin receptor substrate-1; IRS-1; IRS1;
Entrez GeneID	3667;
Swissprot	P35568
WB Predicted band size	180kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 312 (A-T-S(p)-P-A).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/500

	Western blot analysis of extracts from NIH-3T3 cells, using IRS-1 (Ab-312) antibody P41692.
	Western blot analysis of extracts from JK cells (Lane 2), using IRS-1 (Ab-312) antiobdy P41692. The lane on the left is treated with synthesized peptide.
	Immunofluorescence analysis of HeLa cells, using IRS-1 (Ab-312) antibody P41692.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 (Ab-312) antibody P41692.