Rabbit Polyclonal Antibody to KANK2

包装: 1G|100G|500G|1KG|100KG

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别名:Ankyrin repeat domain-containing protein 25; SRC-1-interacting protein; SRC1-interacting protein; Matrix-remodeling-associated protein 3;
应用:IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.Nagase T., DNA Res. 7:143-150(2000).Ota T., Nat. Genet. 36:40-45(2004).Olsen J.V., Cell 127:635-648(2006).

Description

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.Nagase T., DNA Res. 7:143-150(2000).Ota T., Nat. Genet. 36:40-45(2004).Olsen J.V., Cell 127:635-648(2006).

Specification
Aliases	Ankyrin repeat domain-containing protein 25; SRC-1-interacting protein; SRC1-interacting protein; Matrix-remodeling-associated protein 3;
Entrez GeneID	25959;
Swissprot	Q63ZY3
WB Predicted band size	92kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human KANK2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
IHC	1/50-1/100
ICC	1/100-1/500

	Immunofluorescence analysis of A549 cells, using KANK2 antibody P42277.
	Immunohistochemistry analysis of paraffin-embedded human heart tissue using KANK2 antibody P42277.