Rabbit Polyclonal Antibody to KCNA2

包装: 1G|100G|500G|1KG|100KG

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别名:Potassium voltage-gated channel subfamily A member 2, NGK1, Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel HBK5, Voltage-gated potassium channel subunit Kv12, KCNA2
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Description

Potassium channels represent the most complex class of
voltage-gated ion channels from both functional and structural
standpoints. Their diverse functions include regulating
neurotransmitter release, heart rate, insulin secretion, neuronal
excitability, epithelial electrolyte transport, smooth muscle
contraction, and cell volume. Four sequence-related potassium
channel genes – shaker, shaw, shab, and shal – have been identified
in Drosophila, and each has been shown to have human homolog(s).
This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member contains six
membrane-spanning domains with a shaker-type repeat in the fourth
segment. It belongs to the delayed rectifier class, members of
which allow nerve cells to efficiently repolarize following an
action potential. The coding region of this gene is intronless, and
the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Specification
Aliases	Potassium voltage-gated channel subfamily A member 2, NGK1, Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel HBK5, Voltage-gated potassium channel subunit Kv12, KCNA2
Entrez GeneID	3737
Swissprot	P16389
WB Predicted band size	56.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This KCNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451-479 amino acids from the C-terminal region of human KCNA2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	KCNA2 Antibody (C-term) (Cat. #P31524) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCNA2 antibody detected the KCNA2 protein (arrow).
	KCNA2 Antibody (C-term) (P31524)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNA2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.