中文 
别名:JMJD2D应用:WB,IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis. |
| Specification | |
|---|---|
| Aliases | JMJD2D |
| Entrez GeneID | 55693; |
| Swissprot | Q6B0I6 |
| WB Predicted band size | 59kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human lysine (K)-specific demethylase 4D |
| Formulation | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/2000 |
| IHC | 1/50-1/200 |
 |
Gel: 8%SDS-PAGE Lysates (from left to right): Human fetal brain tissue Amount of lysate: 40ug per lane Primary antibody: 1/1100 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 minutes |
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Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using P42827 at dilution 1/50. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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