Rabbit Polyclonal Antibody to KIAA1967

包装: 1G|100G|500G|1KG|100KG

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别名:Protein KIAA1967; Deleted in breast cancer gene 1 protein; DBC.1; DBC-1; p30 DBC
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.Nagase T., DNA Res. 8:319-327(2001).Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002).Olsen J.V., Cell 127:635-648(2006).

Description

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.Nagase T., DNA Res. 8:319-327(2001).Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002).Olsen J.V., Cell 127:635-648(2006).

Specification
Aliases	Protein KIAA1967; Deleted in breast cancer gene 1 protein; DBC.1; DBC-1; p30 DBC
Entrez GeneID	57805;
Swissprot	Q8N163
WB Predicted band size	102kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human KIAA1967.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.