Rabbit Polyclonal Antibody to KLK6

包装: 1G|100G|500G|1KG|100KG

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别名:hK6; Bssp; Klk7; SP59; PRSS9; PRSS18
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer’s disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.

Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer’s disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.

Specification
Aliases	hK6; Bssp; Klk7; SP59; PRSS9; PRSS18
Swissprot	Q92876
WB Predicted band size	27 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein of human KLK6
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/500-1/2000
IHC	1/100-1/300
ELISA	1/2000-1/5000

	Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A375 cells, Primary antibody: P08466(KLK6 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
	The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08466(KLK6 Antibody) at dilution 1/60. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human brain tissue using P08466(KLK6 Antibody) at dilution 1/60. (Original magnification: ×200)