Rabbit Polyclonal Antibody to KMT6

包装: 1G|100G|500G|1KG|100KG

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别名:WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2
应用:WB,IHC,ICC,FCM
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates ‘Lys-9’ and ‘Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate ‘Lys-27’ of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Description

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates ‘Lys-9’ and ‘Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate ‘Lys-27’ of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Specification
Aliases	WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2
Entrez GeneID	2146
Swissprot	Q15910
WB Predicted band size	Calculated MW: 85 kDa; Observed MW: 98 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthesized peptide derived from human KMT6 / EZH2
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200
FCM	1/50-1/100

	Western blot analysis of KMT6 / EZH2 in HEK293 lysates using KMT6 antibody.
	Immunofluorescence analysis of KMT6 in Hela using KMT6 / EZH2 antibody.
	Immunohistochemistry analysis of paraffin-embedded Human tonsil using KMT6 / EZH2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.