Rabbit Polyclonal Antibody to LexA DNA Binding Region

包装: 1G|100G|500G|1KG|100KG

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别名:lexa dna binding region
应用:WB
反应种属:Cyanobacteria
规格：50μl/100μl

Description
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5′-CTGTATATATATACAG-3′. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment.

Description

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5′-CTGTATATATATACAG-3′. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment.

Specification
Aliases	lexa dna binding region
Entrez GeneID	948544
Swissprot	P0A7C2
WB Predicted band size	Refer to figures
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Cyanobacteria
Immunogen	Recombinant Protein of LexA DNA Binding Region
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.