Rabbit Polyclonal Antibody to LILRB2

包装: 1G|100G|500G|1KG|100KG

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别名:ILT4; LIR2; CD85D; LIR-2; MIR10; LILRA6; MIR-10
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Description

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Specification
Aliases	ILT4; LIR2; CD85D; LIR-2; MIR10; LILRA6; MIR-10
Entrez GeneID	10288;
Swissprot	Q8N423
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein corresponding to a region derived from internal residues of human leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
IHC	1/25-1/100

	Immunohistochemical analysis of paraffin-embedded Human cervica cancer tissue using P42772 at dilution 1/30.
	Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using P42772 at dilution 1/30.