Rabbit Polyclonal Antibody to LRRC15

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别名:LIB
应用:IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
Leucine-rich repeats (LRRs) are 20-29 amino acid motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutations in genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 15 (LRRC15, also designated LIB) is a 581 amino acid protein that contains 15 LRR repeats and is involved in cell-cell and/or -extracellular matrix interactions. LRRC15 is frequently overexpressed in multiple tumor types, most notably breast carcinoma. It is also associated with the pathogenesis of Alzheimer’s disease.

Description

Leucine-rich repeats (LRRs) are 20-29 amino acid motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutations in genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 15 (LRRC15, also designated LIB) is a 581 amino acid protein that contains 15 LRR repeats and is involved in cell-cell and/or -extracellular matrix interactions. LRRC15 is frequently overexpressed in multiple tumor types, most notably breast carcinoma. It is also associated with the pathogenesis of Alzheimer’s disease.

Specification
Aliases	LIB
Swissprot	Q8TF66
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Fusion protein of human LRRC15
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/100-1/300
ELISA	1/2000-1/10000

	The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08485(LRRC15 Antibody) at dilution 1/60. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08485(LRRC15 Antibody) at dilution 1/60. (Original magnification: ×200)