Rabbit Polyclonal Antibody to MAP2K7 (Phospho-Ser271)

包装: 1G|100G|500G|1KG|100KG

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别名:PRKMK7; JNKK2; MKK7; MAP2K7; MP2K7
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.Wu Z., Mol. Cell. Biol. 17:7407-7416(1997)Lu X., J. Biol. Chem. 272:24751-24754(1997)Foltz I.N., J. Biol. Chem. 273:9344-9351(1998).

Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.Wu Z., Mol. Cell. Biol. 17:7407-7416(1997)Lu X., J. Biol. Chem. 272:24751-24754(1997)Foltz I.N., J. Biol. Chem. 273:9344-9351(1998).

Specification
Aliases	PRKMK7; JNKK2; MKK7; MAP2K7; MP2K7
Entrez GeneID	5609;
Swissprot	O14733
WB Predicted band size	60kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of Serine271(V-D-S(p)-K-A) derived from Human MAP2K7.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from 3T3 cells treated with insulin using MAP2K7 (Phospho-Ser271) Antibody P40445.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded humanbrain tissue, using MAP2K7 (Phospho-Ser271) antibody P40445 (left)or the same antibody preincubated with blocking peptide (right).