中文 
别名:IB1; JIP1; JIP-1; PRKM8IP应用:WB
反应种属:Human, Mouse, Rat
规格：50μl/100μl
| Description |
|---|
| This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. |
| Specification | |
|---|---|
| Aliases | IB1; JIP1; JIP-1; PRKM8IP |
| Swissprot | Q9UQF2 |
| WB Predicted band size | 78 kDa |
| Host/Isotype | Rabbit IgG |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human MAPK8IP1 |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Application | |
|---|---|
| WB | 1/200-1/1000 |
| ELISA | 1/1000-1/2000 |
 |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: P04985(MAPK8IP1 Antibody) at dilution 1/50, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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