Rabbit Polyclonal Antibody to MAPKAPK2 (Phospho-Ser272)

包装: 1G|100G|500G|1KG|100KG

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别名:MAPK2; MAPKAPK2; RPS6KC1;
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.Zu Y.-L., Biochem. Biophys. Res. Commun. 200-1118-1124(1994)The MGC Project Team; Genome Res. 14:2121-2127(2004)Stokoe D., Biochem. J. 296:843-849(1993)

Description

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.Zu Y.-L., Biochem. Biophys. Res. Commun. 200-1118-1124(1994)The MGC Project Team; Genome Res. 14:2121-2127(2004)Stokoe D., Biochem. J. 296:843-849(1993)

Specification
Aliases	MAPK2; MAPKAPK2; RPS6KC1;
Entrez GeneID	9261;
Swissprot	P49137
WB Predicted band size	45kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of Serine 272(A-I-S(p)-P-G) derived from Human MAPKAPK2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from RAW264.7 cells treated with UV using MAPKAPK2 (Phospho-Ser272) Antibody P40505.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using MAPKAPK2 (Phospho-Ser272) antibody P40505 (left)or the same antibody preincubated with blocking peptide (right).