Rabbit Polyclonal Antibody to MAT1

包装: 1G|100G|500G|1KG|100KG

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别名:AMS1; AdoMet synthetase; EC 2.5.1.6; MAT-I/III; MATA1
应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.Tassan J.-P., EMBO J. 14:5608-5617(1995).Yee A., Cancer Res. 55:6058-6062(1995).Tirode F., Mol. Cell 3:87-95(1999).

Description

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.Tassan J.-P., EMBO J. 14:5608-5617(1995).Yee A., Cancer Res. 55:6058-6062(1995).Tirode F., Mol. Cell 3:87-95(1999).

Specification
Aliases	AMS1; AdoMet synthetase; EC 2.5.1.6; MAT-I/III; MATA1
Entrez GeneID	4331;
Swissprot	P51948
WB Predicted band size	36kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human MAT1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.