Rabbit Polyclonal Antibody to MBD3

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别名:Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3; MBD3;
应用:WB
反应种属:Human,Mouse
规格：50μl/100μl

Description
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (). Recruits histone deacetylases and DNA methyltransferases.Hendrich B., Mol. Cell. Biol. 18:6538-6547(1998).Grimwood J., Nature 428:529-535(2004).Tatematsu K., Genes Cells 5:677-688(2000).

Description

Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (). Recruits histone deacetylases and DNA methyltransferases.Hendrich B., Mol. Cell. Biol. 18:6538-6547(1998).Grimwood J., Nature 428:529-535(2004).Tatematsu K., Genes Cells 5:677-688(2000).

Specification
Aliases	Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3; MBD3;
Entrez GeneID	53615;
Swissprot	O95983
WB Predicted band size	33kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from C-terminal of human MBD3.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.