Rabbit Polyclonal Antibody to MBTPS1

包装: 1G|100G|500G|1KG|100KG

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别名:Endopeptidase S1P; KIAA0091; MBTP1; MBTPS1; membrane-bound transcription factor peptidase
应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.Nakajima T., J. Hum. Genet. 45:212-217(2000).Nagase T., DNA Res. 2:37-43(1995).Bechtel S., BMC Genomics 8:399-399(2007).

Description

Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.Nakajima T., J. Hum. Genet. 45:212-217(2000).Nagase T., DNA Res. 2:37-43(1995).Bechtel S., BMC Genomics 8:399-399(2007).

Specification
Aliases	Endopeptidase S1P; KIAA0091; MBTP1; MBTPS1; membrane-bound transcription factor peptidase
Entrez GeneID	8720;
Swissprot	Q14703
WB Predicted band size	19kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from C-terminal of human MBTPS1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.