Rabbit Polyclonal Antibody to MDM2 (Phospho-Ser186/Ser188)

包装: 1G|100G|500G|1KG|100KG

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别名:Oncoprotein Mdm2; p53-binding protein Mdm2; Ubiquitin-protein ligase E3 Mdm2;
应用:ICC
反应种属:Human
规格：50μl/100μl

Description
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissuesM Zhou, Blood, Mar 1995; 85: 1608 – 1614. Susan M. Mendrysa, Mol. Cell. Biol., Mar 2000; 20: 2023 – 2030. M. Saeed Sheikh, Cancer Res., Jul 1993; 53: 3226 – 3228

Description

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissuesM Zhou, Blood, Mar 1995; 85: 1608 – 1614. Susan M. Mendrysa, Mol. Cell. Biol., Mar 2000; 20: 2023 – 2030. M. Saeed Sheikh, Cancer Res., Jul 1993; 53: 3226 – 3228

Specification
Aliases	Oncoprotein Mdm2; p53-binding protein Mdm2; Ubiquitin-protein ligase E3 Mdm2;
Entrez GeneID	4193;
Swissprot	Q00987
WB Predicted band size	55kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of Ser186/Ser188(H-K-S(p)-D-S(p)-I-S) derived from Human MDM2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.